Name: Hampton Inn Sikeston
Price range: CA $139
Rating: 9

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Your New Madrid Vacation

Our vacation packages to New Madrid provide endless opportunities to delve into new sights, sounds and experiences. And with all the finer details taken care of, you can kick back and enjoy your city escape without a worry in the world. Make your trip to New Madrid even more fulfilling by going sightseeing. New Madrid Historical Museum, River Ridge Winery and Hunter-Dawson State Historic Site are among the top attractions you'll want to explore. Stop daydreaming and start traveling. Explore the wide range of options on Expedia today and put your New Madrid vacation plans in motion!

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New Madrid Hotel Deals

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

New Madrid MO

CA $274

CA $504 total

May 18 - May 19

includes taxes & fees

10/10 Exceptional! (1 review)

The host was very quick to respond and so great to work with for on our stay.

Reviewed on Nov 11, 2025

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

CA $139

CA $157 total

May 31 - Jun 1

includes taxes & fees

9/10 Wonderful! (557 reviews)

Everything was good

Reviewed on May 10, 2026

Reelfoot Lake Inn

1520 State Route 21 East Tiptonville TN

CA $91

CA $105 total

May 19 - May 20

includes taxes & fees

7.2/10 Good! (485 reviews)

Room was sufficient for a 1 night stay. Had a strong smell of disinfectant.

Reviewed on May 4, 2026

See all 58 properties in New Madrid

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.